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TLR11 (Toll-like Receptor 11, Gm287) (FITC)

TLR11 (Toll-like Receptor 11, Gm287) (FITC)

Cat no: T8051-10J

Supplier: United States Biological
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The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry (Intracellular): 0.5-1ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: T8051-10J
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in 10mM Tris, 150mM sodium chloride, 0.05% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998). 2. Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). 3. Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K.,Mudd,S., Shamel,L.,Sovath,S., Goode,J., Alexopoulou,L.,Flavell,R.A. and Beutler,B. Proc. Natl. Acad. Sci. U.S.A. 101 (10), 3516-3521 (2004).
Additional info: Recognizes mouse TLR11. Species Crossreactivity: rat.

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