TLR13, also known as Toll like receptor 13, is a member of the Toll-like receptor (TLR) family of transmembrane proteins comprised of multiple copies of leucine rich repeats in the extracellular domain and a TIR domain. The exact function of this 991aa containing protein is yet unknown but reports suggest that it is closely related to TLR3 and participates in the innate immune response to microbial agents. TLR13 binds to and acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and inflammatory response.
Applications:
Suitable for use in ELISA. Other applications not tested.
Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number:
T8051-30D
Reactivities:
Mouse, Rat
Hosts:
Rabbit
Applications:
ELISA
Size:
100ul
Form:
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type:
Pab
Isotype:
IgG
Purity:
Serum
References:
1. Tabeta,K., Georgel,P., Janssen,E., Du,X., Hoebe,K., Crozat,K., Mudd,S., Shamel,L., Sovath,S., Goode,J., Alexopoulou,L., Flavell,R.A. and Beutler,B. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection., Proc. Natl. Acad. Sci. U.S.A. 101 (10), 3516-3521 (2004).
Additional info:
Recognizes mouse TLR13. Species Crossreactivity: rat.
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