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TLR3, CT (Toll-like Receptor 3, CD283)

TLR3, CT (Toll-like Receptor 3, CD283)

Cat no: T8050-23L

Supplier: United States Biological
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Toll-like receptors (TLRs) are evolutionarily conserved pattern- recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR-3 is known to recognize viral double- stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus. The function of this protein in zebrafish was also characterized. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Control Peptide: T8050-23P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-23L
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Takeda, K. et al. Annu. Rev. Immunol. 21, 335 (2003). 2. Janeway, CA Jr. et al. Annu. Rev. Immunol. 20, 197 (2002). 3. McGettrick, AF. et al. Mol Imm. 41, 577 (2004). 4. Alexopoulou, L. et al. Nature 413, 732 (2001). 5. Guillot, L. et al. J. Biol. Chem. 280, 5571 (2005). 6. Wang, T. et al. Nat. Med. 10, 1366 (2004). 7. Phelan, P.E., et al. 2005; Mol. Immunol. 42(9): 1057-1071.
Additional info: Recognizes zebrafish TLR-3.

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