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TLR4 (Toll-like Receptor 4, hToll, CD284)

TLR4 (Toll-like Receptor 4, hToll, CD284)

Cat no: T8050-30F

Supplier: United States Biological
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The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Ten human homologs of TLRs (TLR1-10) have been described. Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.1-0.5ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human intestine lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-30F
Reactivities: Human, Bovine, Mollusc
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Muzio, M. et al. J. Exp. Med. 187:2097-2101 (1998). 2. Medzhitov, R. et al. Cell. 91:295-298 (1997). 3. Chuang, TH. et al. Biochim. Biophys. Acta. 1518:157-161 (2001). 4. Takeuchi, O. et al. Immunity. 11:443 (1999). 5. Poltorak, A. et al. Proc. Natl. Acad. Sci USA. 97:2163-2167 (2000). 6. Medzhitov, R. et al. Nature. 388:394-397 (1997).
Additional info: Recognizes human TLR4. Species Crossreactivity: bison, chimpanzee, bovine, gorilla, equine, macaque. Species sequence homology: canine and rat.

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