Catalogue number: | 589201 |
Weight: | 0 |
Form: | 96 Well |
P type: | Assay Kits|Cytokines |
Shipping temp: | -20 |
Storage temp: | -20 |
Additional info: | Tumor Necrosis Factor-.alpha. (TNF-.alpha.) is a 17 kDa polypeptide produced primarily by activated monocytes and macrophages. This polypeptide mediates many immune and inflammatory responses, including activation and differentiation of monocytes and macrophages, expression of MHC class I and II, and expression of adhesion molecules on endothelial cells. TNF-.alpha. is considered to be the primary mediator in many inflammatory conditions including toxic shock and sepsis. Cayman's TNF-.alpha. assay is an immunometric (i.e., sandwich) EIA that permits TNF-.alpha. measurements within the range of 0-250 pg/ml, typically with a limit of detection of 1 pg/ml. Inter- and intra-assay CVs of less than 5% can be achieved at most concentrations. This assay allows sensitive, specific analysis of TNF-.alpha. in serum or plasma. |