Toll-Like Receptor 2 Monoclonal Antibody (Clone TL2.1)

Antigen: CHO cells transfected with human TLR2 cDNA . Host: mouse, clone TL2.1 . Cross Reactivity: (+) human and canine TLR2 . Application(s): FC (intracellular and cell surface), ICC, IHC, IP, and WB . TLR2 interacts with TLR1 and coexpression of TLR1 and TLR2 enhances the NF-kB activation in response to a synthetic lipopeptide. Together, they recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.

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SPECIFICATIONS

Catalog Number

13587

Applications

FC, ICC, IHC, IP, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

CHO cells transfected with human TLR2 cDNA

Isotype

IgG2a

Storage Temp

-20

Shipping Temp

-20

Additional Info

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, murine and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection.