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Products TRAF5 Monoclonal Antibody (Clone 55A219)
| Catalogue number: | 10873 |
| Hosts: | Mouse |
| Applications: | Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | fusion protein corresponding to amino acids 77-186 of human TRAF5 |
| P type: | Antibodies|Intracellular Signaling |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-TRAF7). Human TRAF5 is a 557-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-(beta) receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation. |
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