Transforming Growth Factor beta (TGFb)

Transforming growth factor-beta (TGFb) family of proteins has potent hematopoietic regulatory properties ranging from effects on the growth and differentiation of primitive stem cells to the differentiated functions of mature cells. Although most reports have described the inhibitory activities of TGF-beta on hematopoiesis, recent evidence supports the concept that TGF-beta can have both inhibitory and stimulatory actions on these systems. These differences depend on the differentiation state of the target cell and the other cytokines interacting with the cell. Furthermore, TGF-beta has direct bidirectional effects on cell surface expression of many cytokine receptors suggesting that it is part of the mechanism of action of TGF-beta.\n\nApplications:\nSuitable for use in ELISA and Neutralization. Other applications have not been tested.\n\nRecommended Dilutions:\nELISA: < 1ng/well (Sensitivity)\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8250-12

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.5, 5% trehalose.

P Type

Pab

Purity

Purified by Protein A or G affinity chromatography.

Isotype

IgG

Additional Info

Recognizes the latency associated peptide (LAP) from the human TGF-beta precursor. It will neutralize the biological activity of recombinant human LAP. Does not recognize the LAP from TGF-beta 2 precursor.