Synapse differentiation-induced protein 1 (SynDIG1), also known as Transmembrane protein 90B, is a single-pass type II transmembrane protein belonging to the capuchin family of proteins. SynDIG1 is believed to serve in a regulatory role in nascent synapse AMPA receptor content, colocalizing with AMPA receptors at extrasynaptic and synaptic sites. SynDIG1 has been shown to be an activity-regulated transmembrane protein that serves to regulate excitatory synapse development (Kalashnikova, 2010). SynDIG1 expression is specific to the brain where it has been observed in cerebral Purkinje neurons, the hippocampus, excitatory synapses at the cell surface, and postsynaptic cells.
Applications:
Suitable for use in Western Blot, Immunocytochemistry and Immunoprecipitation. Other applications have not been tested.
Recommended Dilutions:
Western Blot: 0.5ug/ml detects FGF14/FHF4 on 10ug of rat brain membrane tissue lysate.
Immunocytochemistry: immunostains dissociated rat hippocampal neurons, as reported by an independent laboratory (Kalashnikova, E., et al.).
Immunoprecipitation: P14 mouse brain extracts were immunoprecipitated as reported by an independent laboratory (Kalashnikova, E., et al.).
Optimal dilutions to be determined by the researcher.
Positive Control:
Rat brain tissue lysate
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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