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TRF2 Monoclonal Antibody (Clone 4A794.15)

Cat no: 13790

TRF2 Monoclonal Antibody (Clone 4A794.15)

Antigen: full length human TRF2 . Host: mouse, clone 4A794.15 . Isotype: IgG1k . Cross Reactivity: (+) human, mouse, muntjac, and rat TRF2 . Application(s): ChIP, ELISA, FC (intracellular), ICC, IF, IHC (frozen sections and paraffin-embedded tissue), IP, and WB . TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length.

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SPECIFICATIONS

Catalog Number

13790

Applications

ELISA, FC, ICC, IF, IHC, IP, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

Full length human TRF2

Isotype

IgG1k

Storage Temp

-20

Shipping Temp

-20

Additional Info

Telomeric repeat binding factor (TRF2) is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role of TRF2 in the prevention of senescence in primary human cells. Inhibition of TRF2 results in apoptosis in a subset of mammalian cell types.

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