Home  >  Products  >  TRIM5a, CT (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)
TRIM5a, CT (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)

TRIM5a, CT (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)

Cat no: T8465-02C

Supplier: United States Biological
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TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the ? variant which also contains a carboxy-terminal B30.2 (SPRY) domain. Expression of TRIM5? variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5? variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5? acts as a natural barrier to cross-species retrovirus transmission. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human uterus cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8465-02C
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A. The tripartite motif family identifies cell compartments. EMBO J. 2001 May 1;20(9):2140-51. PMID: 11331580.1. Reymond A, Meroni G, Fantozzi A, et al. The tripartite motif family identifies cell compartments. EMBO J. 2001;20:2140-51. 2. Stremlau M, Owens CM, Perron MJ, et al. The cytoplasmic body component TRIM5
Additional info: Recognizes human TRIM5a.

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