Home  >  Products  >  TRIM5a, CT (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)
TRIM5a, CT (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)

TRIM5a, CT (Tripartite Motif Containing 5, Tripartite Motif-containing 5, Tripartite Motif Protein 5a, Tripartite Motif Protein TRIM5, TRIM5 alpha, RING Finger Protein 88, RNF88)

Cat no: T8465-02Q

Supplier: United States Biological
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TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a C-terminal B30.2 (SPRY) domain. Expression of TRIM5a variants from humans, rhesus monkeys, and African green monkeys enabled resistance to infection by various retroviruses including HIV-1, albeit at differing efficiencies. All TRIM5a variants could inhibit at least two different retroviruses, but not from those viruses isolated from the same species, suggesting that TRIM5a acts as a natural barrier to cross-species retrovirus transmission. Applications: Suitable for use in ELISA, Western Blot and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human uterus cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8465-02Q
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Reymond, A. et al. EMBO J. 20, 2140 (2001). 2. Stremlau, M. et al. Nature 427, 848 (2004). 3. Hatziioannou, T. et al. Proc. Nat'l. Acad. Sci. USA 101, 10774 (2004).
Additional info: Recognizes human TRIM5 alpha. Species sequence homology: monkey.

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