Troponin C, 1-160aa, Recombinant, Human (fast skeletal muscle troponin C, TNNC2, sTnC)

Troponin C, skeletal muscle, also known as TNNC2, is the central regulatory protein of striated muscle contraction, and modulates the Ca2+-activation characteristics of muscle fibers. Troponin has 3 subunits, Troponin I(Tn-1), Troponin T(Tn-T) and Troponin C(Tn-C). Tn-I subunit inhibits actomyosin ATPase and Tn-T subunit binds tropomyosin and Tn-C, while Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. Mutations in all components of this complex have been associated with skeletal muscle disease.\n\nSource:\nRecombinant human Troponin C was expressed in E.coli.\n\nMolecular Weight: 18.1kD (160aa)\n\nAA Sequence:\nMTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8665-10A

Size

100ug

Form

Supplied as a liquid in 20 mM Tris-HCl buffer, pH 8.0, 1mM DTT, 100mM sodium chloride, 10% glycerol.

Purity

(same/more than)95% (SDS-PAGE)

References

1. Prentice H., et al. (1994). J Mol Cell Cardial. 26(10):1393-401. 2. Gahlmann R., et al. (1988). J Mol Biol. 201(2):379-91. 3. Li Y., et al. (2008). Hereditas. 145(6):274-82.