Troponin I, Cardiac, Recombinant, Human (cTnI, CMH7, Familial Hypertrophic Cardiomyopathy 7, MGC116817, TNNC1, Troponin I Type 3 Cardiac, TNNI3)

Troponin, working in conjunction with tropomyosin, functions as a molecular switch, regulating muscle contraction in response to changes in the intracellular Ca2+ concentration. Troponin consists of three subunits, the Ca2+-binding subunit troponin C (TnC), the tropomyosin-binding subunit troponin T (TnT), and the inhibitory subunit troponin I (TnI). Troponin I binds to actin in thin myofilaments to hold the actin-tropomyosin complex in place, because of which myosin cannot bind to actin in relaxed muscle. When Calcium binds to the Troponin C it causes certain confomational changes which leads to dislocation of troponin I. The letter

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SPECIFICATIONS

Catalog Number

T8665-18G

Size

50ug

Form

Supplied as a liquid in 6M Urea, 50mM Tris, pH 8.0.

Purity

(same/more than) 95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified. Endotoxin:< 0.1ng/ug (IEU/ug).

References

1. Frequency and clinical expression of cardiac troponin I mutations in 748 consecutive families with hypertrophic cardiomyopathy. Mogensen J, Murphy RT, Bahl A, McKenna WJ, J Am Coll Cardiol 2004 Dec 21;44(12):2315-25 2. Incidence and significance of cardiac troponin I release in severe trauma patients. Edouard AR, Felten ML, Cosson C, Anesthesiology 2004 Dec;101(6):1262-8 3. Elevated serum cardiac troponin I level in a patient after a grand mal seizure and with no evidence of cardiac disease. Brobbey A, Ravakhah K, Am J Med Sci 2004 Sep;328(3):189-91 4. Structure of the Mg2+-loaded C-lobe of cardiac troponin C bound to the N-domain of cardiac troponin I: comparison with the Ca2+-loaded structure. Finley NL, Howarth JW, Biochemistry 2004 Sep 14;43(36):11371-9 5. Plasma concentrations of cardiac troponin I in newborn infants. Araujo K, da Silva J, Kopelman B, Clin Chem 2004 Sep;50(9):1717-8 6. Multicenter evaluation of the TOSOH AIA-pack second-generation cardiac troponin I assay. Pagani F, Stefini F, Toppino M, Iervasi A, Clin Chem 2004 Sep;50(9):1707-9.