Troponin T, Cardiac (Troponin T Cardiac Muscle, TnTC, Troponin T Type 2 (Cardiac), Troponin T2, TNNT2, Cardiac Muscle Troponin T, cTnT, CMD1D, CMH2, MGC3889)

Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations within the protein have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for the gene undergo alternative splicing that results in many tissue-specific isoforms.\n\nApplications: \nSuitable for use in ELISA and immunoaffinity purification. Other applications not tested.\n\nRecommended Dilutions:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap

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SPECIFICATIONS

Catalog Number

T8665-23B

Size

1mg

Applications

ELISA

Hosts

Mouse

Reactivities

Hum, Mouse, Bov, Can, Goat, Rabbit

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG1

Additional Info

Recognizes human cardiac Troponin T. Recognizes an epitope located between aa residues 70 and 94 of cTnT. No cross-reactivity with human skeletal troponin T. Species Crossreactivity: bovine, goat, canine, rabbit, mouse and fish. Does not recognize porcine, feline and rat.