Home  >  Products  >  Troponin T, Cardiac (Troponin T Cardiac Muscle, TnTC, Troponin T Type 2 (Cardiac), Troponin T2, TNNT2, Cardiac Muscle Troponin T, cTnT, CMD1D, CMH2, MGC3889)
Troponin T, Cardiac (Troponin T Cardiac Muscle, TnTC, Troponin T Type 2 (Cardiac), Troponin T2, TNNT2, Cardiac Muscle Troponin T, cTnT, CMD1D, CMH2, MGC3889)

Troponin T, Cardiac (Troponin T Cardiac Muscle, TnTC, Troponin T Type 2 (Cardiac), Troponin T2, TNNT2, Cardiac Muscle Troponin T, cTnT, CMD1D, CMH2, MGC3889)

Cat no: T8665-24C

Supplier: United States Biological
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The troponin complex is located on the thin filament of striated muscle and is composed of three component polypeptides: troponin T (TNNT1; TNNT2), troponin I (TNNI1; TNNI2; TNNI3), and troponin C (TNNC) (1).Troponin T type 2 (TNNT2) is a cardiac troponin T isoform expressed in the human heart, that is essential for calcium-regulated myofibrillar ATPase activity (2). Troponin T (TnT) anchors the complex to the thin filaments in vertebrate striated muscle, and functions as a regulatory system for muscle contraction in response to changes to intracellular calcium ion concentration (3). All subunits of Tnnt2 have been associated with hypertrophic cardiomyopathy (HCM) (4). Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:100,000-1:500,000 Immunoprecipitation: 1:10 Immunohistochemistry (Paraffin): 1:100-1:250 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: T8665-24C
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA, 0.01% sodium azide, 40% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Townsend, P.J., et al., Genomics 21(2): 311-316 (1994). 2. Anderson, P.A., et al., Circ. Res. 76(4): 681-686 (1995). 3. Gian-Franco, Sferrazza, et al., Biochem. Biophys. Res. Commun. 357(1): 32
Additional info: Recognizes human Troponin T type 2 at 39/34kD.

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