

Supplier:
Cayman Chemical CompanyCat no: 10009397
Tryptophan Hydroxylase (Phospho-Ser58) Polyclonal Antibody
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SPECIFICATIONS
Catalog Number
10009397
Applications
WB
Hosts
Rabbit
Form
1 ea
P Type
Antibodies
Weight
0
Antigen
phosphopeptide corresponding to amino acid residues surrounding phospho-Ser58 of TPH
Storage Temp
-20
Shipping Temp
-20
Additional Info
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CaM K II). Both PKA and CaM K II phosphorylate Ser58 which lies within the regulatory domain of TPH.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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