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Tumor Necrosis Factor Receptor Associated Factor 3, NT (TRAF-3)

Cat no: T9161-56N

Tumor Necrosis Factor Receptor Associated Factor 3, NT (TRAF-3)

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll- like receptor (IL-1/TLR) superfamily (1). TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr \nvirus transforming protein LMP1 (2,3). Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kB (4). Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) in association with TRAF2 \nand the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbR (5). \n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-2ug

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SPECIFICATIONS

Catalog Number

T9161-56N

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.\n

P Type

Pab

Purity

Purified by immunoaffinity chromatography.\n

Isotype

IgG

References

1. Arch RH, et al., Genes Dev. 1998; 12:2821- 30. 2. Cheng G, et al., Science 1995; 267:1494-8. 3. Mosialos G, et al., Cell 1995; 80:389- 99. 4. van Eyndhoven WGet al. Mol. Immunol. 1999; 36:647-58. 5. Kuai J, et al., J. Biol. Chem. 2003; 278:14363-9.

Additional Info

Recognizes human TRAF3. Species Crossreactivity: mouse and rat.

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