Home  >  Products  >  UNC5CL (UNC5C-like Protein, Protein Unc-5 Homolog C-like, ZU5 and Death Domain-containing Protein, ZUD)
UNC5CL (UNC5C-like Protein, Protein Unc-5 Homolog C-like, ZU5 and Death Domain-containing Protein, ZUD)

UNC5CL (UNC5C-like Protein, Protein Unc-5 Homolog C-like, ZU5 and Death Domain-containing Protein, ZUD)

Cat no: U1607-50A

Supplier: United States Biological
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UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apopotosis induced by TNF and TRAIL. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 0.3-1ug/ml, observed in human kidney and ovary lysates on ~55kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: U1607-50A
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Zhang J, Xu LG, Han KJ, Shu HB. Identification of a ZU5 and death domain-containing inhibitor of NF-kappaB. J Biol Chem. 2004 Apr 23;279(17):17819-25.
Additional info: Recognizes human UNC5CL.

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