Home  >  Products  >  Urokinase Plasminogen Activator (uPA) (FITC)

Urokinase Plasminogen Activator (uPA) (FITC)

Cat no: U2615-05E


Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Urokinase Plasminogen Acitivator is a serine protease (SERPIN) that converts plasminogen into the active protease plasmin. uPA is secreted from cells as an inactive ~55kD precursor which is activated to the two-chain form consisting of an A and B-chain. The active high MW form is further processed by removal of an amino-terminal fragment to an active low MW form (~35kD). uPA is a serine protease that activates plasminogen to plasmin. uPA is involved in the degradation of the vascular basement membrane and extracellular matrix. By catalyzing plasmin formation, the uPA can generate widespread extracellular proteolysis and thereby play an important role in physiological and pathological processes. High levels of uPA and plasminogen activator inhibitor type 1 (PAI-1) in breast cancer tissue extracts have been associated with rapid disease progression. The malignant phenotype of prostatic tumor cells correlates with the expression of both uPA and its cell-membrane receptor (uPAR). Applications: Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.
Catalogue number: U2615-05E
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 1mg
Form: Supplied as a liquid in 0.05M sodium phosphate, 0.1M sodium chloride, 1mM EDTA, pH 6.6. Labeled with fluorescein isothiocyanate (FITC).
P type: Pab
Isotype: IgG
Purity: Purified by protein A affinity chromatography.
Additional info: Recognizes human Urokinase Plasminogen Activator

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*

Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave