A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC50=4-5uM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34uM.
Sequence:
1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1- pyrrolidinyl)-ethanone
Solubility:
DMSO (20mg/ml)
Molecular Weight:
~300.37
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