Home  >  Products  >  Valosin Containing Protein (VCP, Valosin-containing Protein, 15S Mg(2+)-ATPase p97 Subunit, ATPase p97, IBMPFD, MGC131997, MGC148092, MGC8560, p97, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TER-ATPase, TERA, Yeast Cdc48p Homolog)

Valosin Containing Protein (VCP, Valosin-containing Protein, 15S Mg(2+)-ATPase p97 Subunit, ATPase p97, IBMPFD, MGC131997, MGC148092, MGC8560, p97, Transitional Endoplasmic Reticulum ATPase, TER ATPase, TER-ATPase, TERA, Yeast Cdc48p Homolog)

Cat no: V1035-20A


Supplier: United States Biological
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Valsolin Containing Protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. p97/VCP (valosin containing protein) belongs to the AAA ATPase family, predicted molecular weight 97kD. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:5000-1:15,000 Immunohistochemistry: paraffin sections Immunoprecipitation: 1-4ug/mg of lysate Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V1035-20A
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in TBS, 0.1% BSA, 0.09% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human Valosin Containing Protein. The epitope maps to a region between residue 750 and the C-terminus (residue 806) of human VCP (NP_009057.1).Species Crossreactivity: mouse.

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