Home  >  Products  >  VAMP 2 (Vesicle Associated Membrane Protein 2, Vesicle-associated Membrane Protein 2, VAMP2, VAMP-2, FLJ11460, Synaptobrevin 2, Synaptobrevin-2, SYB 2, SYB2, SYB-2)
VAMP 2 (Vesicle Associated Membrane Protein 2, Vesicle-associated Membrane Protein 2, VAMP2, VAMP-2, FLJ11460, Synaptobrevin 2, Synaptobrevin-2, SYB 2, SYB2, SYB-2)

VAMP 2 (Vesicle Associated Membrane Protein 2, Vesicle-associated Membrane Protein 2, VAMP2, VAMP-2, FLJ11460, Synaptobrevin 2, Synaptobrevin-2, SYB 2, SYB2, SYB-2)

Cat no: V2024-02U

Supplier: United States Biological
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VAMP-2 is a member of the vesicle-associated membrane protein (VAMP):synaptobrevin family, which are 18kD integral membrane proteins originally characterized in synaptic vesicles. The protein forms a stable complex with syntaxin, synaptosomal-associated protein and synaptotagmin which are main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP-2 plays a key role in the fusion of synaptic vesicles. VAMP-2 is also expressed in non-neuronal tissue and participates in regulated exocytosis, such as insulin-regulated translocation of glucose transporter-4 (GLUT4)-containing vesicles in adipocytes and insulin secretion in pancreatic beta-cells. In human, the pathological role of the protein has been identified in familial infantile myasthenia (FIMG). The rat VAMP-2 gene is localized on chromosome 10q24. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Brain Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2024-02U
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Alternative names: Vesicle-associated Membrane Protein 2 (Synaptobrevin 2)
References: 1. Martincic, I. et al. J. Biol. Chem. 272:26991-26998 (1997). 2. Archer, BT. et al. J. Biol. Chem. 265:17267-17273 (1990). 3. Weir, ML. et al. Biochem. J. 333:247-251 (1998).
Additional info: Recognizes rat VAMP-2. Species Crossreactivity: mouse. Species sequence homology: human.

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