Vangl-2, CT (Vang-like Protein 2, Protein Strabismus, Protein Trilobite, Van Gogh-like Protein 2, Vangl2, Stbm, Tri)

Supplier:

United States Biological

Cat no: V0499-18

Vangl-2, CT (Vang-like Protein 2, Protein Strabismus, Protein Trilobite, Van Gogh-like Protein 2, Vangl2, Stbm, Tri)

Van gogh-like 2 (vangl-2) is a transmembrane protein encoded by strabismus (stbm). Research into the involvment of tag1, lama1 and stbm with migration of facial branchiomotor neurons (FBMNs) in the zebrafish hindbrain suggests that vangl-2 participates, together with tag1 and lama1, in a common mechanism to regulate FBMN migration by incorporating signaling between the FBMN and its environment. In another separate study of zebrafish tailbud elongation and its relation to the cadherin subfamily of cell- cell adhesion molecules, vangl-2, associated with the Wnt (non-canonical) signaling/planar cell polarity pathway, interacts with N-cadherin in a cooperative manner to mediate tail morphogenesis. The vang/stbm gene is a key component in planar cell polarity signaling in Drosophila in addition to its role in regulating two distinct Wnt signals in order to influence vertebrate gastrulation patterning and morphogenesis.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:5000-1:20,000\nOptimal dilutions to be determined by the researcher.\n\nControl Peptide: V0499-18P\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

V0499-18

Size

250ul

Applications

ELISA

Hosts

Rabbit

Reactivities

ZF/Fish

Form

Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Sittaramane, V., et al. (2009) Dev. Biol. 325(2): 363-373. 2. Harrington, MJ., et al. (2007) BMC Dev. Biol. 7(1): 130. 3. Heisenberg, C-P. and Tada, M. (2002) Curr. Biol. 12(4): R126-R128.

Additional Info

Recognizes zebrafish Vangl-2.

Read more on Supplier website

SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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