Home  >  Products  >  Vangl-2, NT (Vang-like Protein 2, Protein Strabismus, Protein Trilobite, Van Gogh-like Protein 2, Vangl2, Stbm, Tri)
Vangl-2, NT (Vang-like Protein 2, Protein Strabismus, Protein Trilobite, Van Gogh-like Protein 2, Vangl2, Stbm, Tri)

Vangl-2, NT (Vang-like Protein 2, Protein Strabismus, Protein Trilobite, Van Gogh-like Protein 2, Vangl2, Stbm, Tri)

Cat no: V0499-18A

Supplier: United States Biological
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Van gogh-like 2 (vangl-2) is a transmembrane protein encoded by strabismus (stbm). Research into the involvment of tag1, lama1 and stbm with migration of facial branchiomotor neurons (FBMNs) in the zebrafish hindbrain suggests that vangl-2 participates, together with tag1 and lama1, in a common mechanism to regulate FBMN migration by incorporating signaling between the FBMN and its environment. In another separate study of zebrafish tailbud elongation and its relation to the cadherin subfamily of cell- cell adhesion molecules, vangl-2, associated with the Wnt (non-canonical) signaling/planar cell polarity pathway, interacts with N-cadherin in a cooperative manner to mediate tail morphogenesis. The vang/stbm gene is a key component in planar cell polarity signaling in Drosophila in addition to its role in regulating two distinct Wnt signals in order to influence vertebrate gastrulation patterning and morphogenesis. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Immunohistochemistry: 1:50-1:200 Optimal dilutions to be determined by the researcher. Control Peptide: V0499-18Q Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V0499-18A
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Sittaramane, V., et al. (2009) Dev. Biol. 325(2): 363-373. 2. Harrington, MJ., et al. (2007) BMC Dev. Biol. 7(1): 130. 3. Heisenberg, C-P. and Tada, M. (2002) Curr. Biol. 12(4): R126-R128.
Additional info: Recognizes zebrafish Vangl-2.

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