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VAP-1 (Vascular Adhesion Protein 1, Amine Oxidase Copper-Containing 3, AOC3, Semicarbazide-Sensitive Amine Oxidase, SSAO, HPAO, Membrane copper amine oxidase, Semicarbazide-sensitive amine oxidase)

VAP-1 (Vascular Adhesion Protein 1, Amine Oxidase Copper-Containing 3, AOC3, Semicarbazide-Sensitive Amine Oxidase, SSAO, HPAO, Membrane copper amine oxidase, Semicarbazide-sensitive amine oxidase)

Cat no: V2095-02E

Supplier: United States Biological
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Vascular Adhesion Protein 1 (VAP-1), also called AOC3 (amine oxidase copper-containing 3) or SSAO (semicarbazide-sensitive amine oxidase) is a type II transmembrane sialoglycoprotein that is upregulated on endothelial cells by inflammation. The 170kD disulfide-linked homodimer of 763 aa units is an ectoenzyme that deaminates amines, forming aldehydes and hydrogen peroxide. It also mediates lymphocyte rolling, adhesion and possibly extravasation during inflammation. Adipocytes can release a soluble form via metalloproteinase cleavage. Human and mouse VAP-1 share 83% aa identity. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:64000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: V2095-02E
Reactivities: Human, Mouse, Rat
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Forster-Horvath C, Dome B, Paku S, Ladanyi A, Somlai B, Jalkanen S, Timar J. Loss of vascular adhesion protein-1 expression in intratumoral microvessels of human skin melanoma. Melanoma Res. 2004 Apr;14(2):135-40.
Additional info: Recognizes human AOC3. Species Crossreactivity: Mouse and rat.

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