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Vascular Endothelial Growth Factor B, Recombinant, Human (VEGFB, VEGF-B, VEGF-related Factor, VRF, VEGFL)

Cat no: 149582

Vascular Endothelial Growth Factor B, Recombinant, Human (VEGFB, VEGF-B, VEGF-related Factor, VRF, VEGFL)

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a пїЅcysteine knotпїЅ like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38kD disulfide-linked homodimeric protein consisting of two 167aa polypeptide chains.\n\nSource:\nRecombinant protein corresponding to human VEGF-B, expressed in E. coli.\n\nEndotoxin:\n<0.1ng/ug (1EU/ug)\n\nAA Sequence:\nPVSQPDAPGH QRKVVSWIDV YTRATCQPRE VVVPLTVELM GTVAKQLVPS CVTVQRCGGC CPDDGLECVP TGQHQVRMQI LMIRYPSSQL GEMSLEEHSQ CECRPKKKDS AVKPDSPRPL CPRCTQHHQR PDPRTCRCRC RRRSFLRCQG RGLELNPDTC RCRKLRR\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

149582

Size

5ug

Form

Supplied as a lyophilized powder.

Purity

~98% (SDS-PAGE and HPLC)

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