Home  >  Products  >  Vascular Endothelial Growth Factor Receptor 2, phosphorylated (Tyr1175) (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)
Vascular Endothelial Growth Factor Receptor 2, phosphorylated (Tyr1175) (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)

Vascular Endothelial Growth Factor Receptor 2, phosphorylated (Tyr1175) (VEGF Receptor 2, VEGFR 2, VEGFR2, VEGFR-2, VEGFR, CD309 Antigen, Fetal Liver Kinase 1, FLK1, Kinase Insert Domain Receptor, KDR, KRD1, Ly73, Protein Tyrosine Kinase Receptor FLK1)

Cat no: V2110-19B

Supplier: United States Biological
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VEGFR2 is the major VEGF receptor in human malignancies. VEGFR2 is highly expressed in colon cancer endothelium and relates to increased tumor vascularity and high metastatic ability. Binding of VEGF to VEGFR2 on endothelial cells results in receptor phosphorylation and triggering of a cascade of events leading to endothelial cell proliferation, migration, apoptosis inhibition and maturation of vascular structures. Human VEGFR2 gene is mapped to chromosome 4q11-q12. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 1:50-1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2110-19B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Chlouverakis, E. et al. European Journal of Clinical Investigation. 37:878-886 (2007).
Additional info: Recognizes human VEGFR2, phosphorylated at Tyr1175. Species Crossreactivity: mouse and rat.

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