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Vascular Endothelial Growth Factor Receptor 3 (VEGF3, Flt4)

Cat no: V2110-20J

Vascular Endothelial Growth Factor Receptor 3 (VEGF3, Flt4)

Vascular endothelial growth factor receptor 3 (VEGFR3) is a 195kD membrane receptor tyrosine kinase. VEGF receptors are characterized by the presence of seven extracellular immunoglobulin (Ig)-like domains followed by a membrane-spanning domain and a conserved intracellular tyrosine kinase domain (1). VEGF Receptor 3 expression is largely restricted to adult lymphatic endothelium and is thought to control lymphangiogenesis (1,2). Binding of VEGF-C/VEGF-D to VEGFR3 results in transphosphorylation of tyrosine residues in its intracellular domain, recruitment of signaling molecules and activation of ERK1/2 and Akt signaling cascades (1,3). \n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

V2110-20J

Size

100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, 50% glycerol, 0.02% sodium azide.

P Type

Mab

Purity

As reported

Isotype

IgG

References

(1) Robinson, C.J. and Stringer, S.E. (2001) J. Cell Sci.114, 853

Additional Info

Detects transfected levels of human VEGFR3. This antibody does not cross-react with other family members.

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