VASP is a novel phosphoprotein associated with microfilaments, focal adhesions and highly dynamic membranes not only in human platelets but also in a wide variety of other cells and tissues. VASP was originally discovered, purified and characterized as a protein which is phosphorylated in response to both cAMP and cGMP elevating vasodilators and platelet inhibitors mediated by cAMP and cGMPdependentprotein kinases (cAK, cGK). The protein is involved in signal transduction and cellular motility. Morever as the protein contains both actin binding and actin monomer-nucleating capabilities, the molecule is also of particular interest for reorganization of the cytoskeleton. Human VASP gene is localized on chromosomal region 19q13.2-q13.3.
Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Western Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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