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Products VE-Cadherin Polyclonal Antibody
| Catalogue number: | 160840 |
| Hosts: | Rabbit |
| Applications: | Immunocytochemistry, Immunoprecipitation, Western Blot |
| Weight: | 0 |
| Form: | 1 ea |
| Antigen: | human VE-cadherin amino acids 259-434 |
| P type: | Antibodies |
| Shipping temp: | -20 |
| Storage temp: | -20 |
| Additional info: | VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions. The protein belongs to the cadherin superfamily of adhesion molecules. VE-cadherin plays a pivotal role in vascular structure assembly. Endothelial cells fail to organize in a vessel-like pattern if the VE-cadherin gene is disrupted. In this aspect, VE-cadherin is a critical component of a protein complex which controls endothelial cell tube formation. VE-cadherin is also critical for maintenance of the endothelium. Following disruption of endothelial cell monolayers with an anti-VE-cadherin antibody, endothelial cells rapidly resynthesize VE-cadherin in order to restore their intracellular junctions. Human VE-cadherin has a molecular mass of approximately 87,500 based on the deduced amino acid sequence and is 83% and 79% homologous to porcine and mouse VE-cadherin at the amino acid level. |
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