

Supplier:
Cayman Chemical CompanyCat no: 160840
VE-Cadherin Polyclonal Antibody
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SPECIFICATIONS
Catalog Number
160840
Applications
ICC, IP, WB
Hosts
Rabbit
Form
1 ea
P Type
Antibodies
Weight
0
Antigen
human VE-cadherin amino acids 259-434
Storage Temp
-20
Shipping Temp
-20
Additional Info
VE-cadherin (vascular endothelium cadherin), also known as Cadherin-5, is an endothelial cell-specific adhesion molecule localized at intracellular junctions. The protein belongs to the cadherin superfamily of adhesion molecules. VE-cadherin plays a pivotal role in vascular structure assembly. Endothelial cells fail to organize in a vessel-like pattern if the VE-cadherin gene is disrupted. In this aspect, VE-cadherin is a critical component of a protein complex which controls endothelial cell tube formation. VE-cadherin is also critical for maintenance of the endothelium. Following disruption of endothelial cell monolayers with an anti-VE-cadherin antibody, endothelial cells rapidly resynthesize VE-cadherin in order to restore their intracellular junctions. Human VE-cadherin has a molecular mass of approximately 87,500 based on the deduced amino acid sequence and is 83% and 79% homologous to porcine and mouse VE-cadherin at the amino acid level.
Applications
ELISA, IF, IP, WB
Hosts
Rabbit
Applications
ELISA, IP, WB
Hosts
Rabbit
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