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VEGI (TL1A, Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-related Molecule 1, Vascular Endothelial Cell Growth Inhibitor, TNFSF15, TL1)

VEGI (TL1A, Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-related Molecule 1, Vascular Endothelial Cell Growth Inhibitor, TNFSF15, TL1)

Cat no: V2121-35B

Supplier: United States Biological
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Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and up-regulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-kB activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is up-regulated by pro-inflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1, also called vascular ehdothelial growth inhibotor (VEGI). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2121-35B
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by DEAE chromatography.
References: 1. Chinnayan, AM. et al. Science 274, 990 (1996). 2. Kitson, J. et al. Nature 384, 372 (1996). 3. Screaton, GR. et al. Proc. Natl. Acad. Sci. USA 94, 4615 (1997). 4. Bodmer, JL. et al. Immunity 6, 79 (1997). 5. Marsters, SA. et al. Curr. Biol. 6, 1669 (1996). 6. Migone, TS. et al. Immunity 16, 479 (2002). 7. Pitti, RM. et al. Nature 396, 699 (1998). 8. Yu KY. et al. J. Biol. Chem. 274, 13733 (1999).
Additional info: Recognizes human TL1A. Species Crossreactivity: mouse.

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