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Vimentin (FLJ36605, VIM)

Vimentin (FLJ36605, VIM)

Cat no: V2122-14A

Supplier: United States Biological
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The cytoskeleton consists of three types of cytosolic fibers: microfilaments (actin filaments), intermediate filaments and microtubules. Major types of intermediate filaments are distinguished by their cell specific expression: cytokeratins (epithelial cells), glial fibrillary acidic protein (GFAP) (glial cells), desmin (skeletal, visceral and certain vascular smooth muscle cells), vimentin (mesenchyme origin) and neurofilaments (neurons). GFAP and vimentin form intermediate filaments in astroglial cells and modulate their motility and shape (1). In particular, vimentin filaments are present at early developmental stages, while GFAP filaments are characteristic of differentiated and mature brain astrocytes. Thus, GFAP is commonly used as a marker for intracranial and intraspinal tumors arising from astrocytes (2). Vimentin is present in sarcomas, but not carcinomas, and its expression is examined in conjunction with that of other markers to distinguish between the two (3). Vimentin
Catalogue number: V2122-14A
Reactivities: Human, Mouse, Rat, Non-Human Primate
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, less than 0.02% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG
Purity: Purified
References: (1) Eng, L.F. et al. (2000) Neurochem. Res. 25, 1439-1451. (2) Goebel, H.H. et al. (1987) Acta Histochem. Suppl. 34, 81-93. (3) Leader, M. et al. (1987) Histopathology 11, 63-72. (4) Helfand, B.T. et al. (2004) J. Cell Sci. 117, 133-141. (5) Tang, D.D. et al. (2005) Biochem. J. 388, 773-783. (6) Fomina, I.G. et al. (1990) Klin. Med. (Mosk.) 68, 125-127. (7) Nieminen, M. et al. (2006) Nat. Cell Biol. 8, 156-162.
Additional info: Recognizes endogenous levels of total vimentin. Species Crossreactivity: monkey, mouse, rat.

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