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Vitamin D Receptor (VDR, vitamin D (1,25- dihydroxyvitamin D3) receptor , HGNC:12679, NR1I1, vitamin D (1,25-dihydroxyvitamin D3) receptor)

Vitamin D Receptor (VDR, vitamin D (1,25- dihydroxyvitamin D3) receptor , HGNC:12679, NR1I1, vitamin D (1,25-dihydroxyvitamin D3) receptor)

Cat no: V2130-01C

Supplier: United States Biological
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Vitamin D receptor (VDR) is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or transrepression of specific gene products. In humans, the vitamin D receptor is encoded by the VDR gene. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows similarity of sequence to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Applications: Suitable for use in Western Blot, Immunoprecipitation, Inhibition and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 0.5-2ug/ml detects Vitamin D in MCF7 cell lysates Immunohistochemistry (Paraffin): 1:100. Antigen retrieval wit sodium citrate, pH 6.0 is recommended Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: V2130-01C
Reactivities: Human
Hosts: Rat
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG2b,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Larriba, M. J., et al. (2007). Endocr Relat Cancer. 14: 141-51. 2. Mikaelian, I. et al. (2004). Toxicology Pathology. 32: 181-191. 3. Palmer, H. G., et al. (2004). Nat Med. 10: 917-19. 4. Jimenez-Lara, A. et al. (1999). Endocrinology. 140 (6): 2898-2907.
Additional info: Recognizes human vitamin D receptor. Species Crossreactivity: Broad species reactivity expected

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