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WDR68, Recombinant, Human, aa19-295, His-tag (DCAF7, DDB1- and CUL4-associated Factor 7, WD Repeat-containing Protein 68, WD Repeat-containing Protein An11 Homolog, HAN11)

Cat no: W1006-76

WDR68, Recombinant, Human, aa19-295, His-tag (DCAF7, DDB1- and CUL4-associated Factor 7, WD Repeat-containing Protein 68, WD Repeat-containing Protein An11 Homolog, HAN11)

DCAF7, involved in craniofacial development. This protein acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. This protein associates with DIAPH1 and controls GLI1 transcriptional activity. This protein could be involved in normal and disease skin development.\n\nSource:\nRecombinant corresponding to aa19-295 from human DCAF7 fused to His-tag at N-terminal expressed in E.coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MVYAMNWSVR PDKRFRLALG SFVEEYNNKV QLVGLDEESS EFICRNTFDH PYPTTKLMWI PDTKGVYPDL LATSGDYLRV WRVGETETRL ECLLNNNKNS DFCAPLTSFD WNEVDPYLLG TSSIDTTCTI WGLETGQVLG RVNLVSGHVK TQLIAHDKEV YDIAFSRAGG GRDMFASVGA DGSVRMFDLR HLEHSTIIYE DPQHHPLLRL CWNKQDPNYL ATMAMDGMEV VILDVRVPCT PVARLNNHRA CVNGIAWAPH SSCHICTAAD DHQALIWD\n\nMolecular Weight: \n~33.6kD\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

W1006-76

Size

100ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.4M urea, 1mM DTT.

Purity

~90% (SDS-PAGE)

References

1. Morita K., et al. (2006) J. Dermatol. Sci. 44:11-20. 2. Jin J., et al. (2006) Mol. Cell. 23:709-721.

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