Cell-permeable. Selectively inhibits the tyrosine kinase activity of Jak3 with an IC?? value of 78uM without affecting the enzymatic activity of JAK1, JAK2, or other protein tyrosine kinases. Also helps to induce rat bone marrow stromal cells (MSCs) to neuronal cells.
Solubility:
DMSO (~50mg/ml)
Molecular Weight:
~297.31
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.