WNT2B (Wingless-type MMTV Integration Site Family Member 2B, Protein Wnt-2b, Protein Wnt-13, WNT13, XWNT2)

This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in Human development as well as Human carcinogenesis. This gene produces two alternative transcript variants. WNT2B is a paralogue of WNT2 and encodes WNT2B1 and WNT2B2 isoforms due to alternative splicing using alternative promoter.\n\nApplications:\nSuitable for use in Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 5ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman brain, cerebellum\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

W3035-40C

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Skin Pharmacol Physiol 17:258-66 Molecular Analysis of the Effect of Topical Imiquimod Treatment of HPV 2/27/57-Induced Common Warts. Jacobs S, Grussendorf-Conen EI, RГ¶sener I, and RГјbben A. 2. J Comp Neurol 2004 Jun. 474:276-88 Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. Abu-Khalil A, Fu L, Grove EA, Zecevic N, and Geschwind DH. 3. Osteoarthritis Cartilage 2004 Jun. 12:497-505 Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts. Yates KE. 4. Dev Biol 2004 Jan. 265:61-74 Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Burns RC, Fairbanks TJ, Sala F, De Langhe S, Mailleux A, Thiery JP, Dickson C, Itoh N, Warburton D, Anderson KD, and Bellusci S. 5. Cytogenet Genome Res 2003 . 101:84-9 Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes. Hiraiwa H, Sawazaki T, Suzuki K, Fujishima-Kanaya N, Toki D, Ito Y, Uenishi H, Hayashi T, Awata T, and Yasue H.

Additional Info

Recognizes human WNT2B. Species Sequence Homology: mouse and rat.