WRN (Werner Syndrome ATP-dependent Helicase, DNA Helicase RecQ-like Type 3, RecQ3, RECQL3, Exonuclease WRN, RecQ Protein-like 2, RECQL2)

The RecQ family of DNA and RNA helicases is a family of enzymes that has been shown to be important to genome integrity (1). Members of this family function in several DNA repair processes including double strand break repair, homologous recombination, and re-initiation of DNA replication at stalled replication forks (2,3). Mutations in RecQ helicase family members results in syndromes that display varying types of chromosomal abnormalities and overall genomic instability (1). WRN is a member of the RecQ family that has been identified as the gene underlying Werner

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SPECIFICATIONS

Catalog Number

W9000-02D

Size

100ul

Applications

ICC, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, less than 0.02% sodium azide, 50% glycerol.

P Type

Mab

Purity

Purified

Isotype

IgG1

References

(1) Cobb, J.A. et al. (2002) FEBS Lett 529, 43-8. (2) Ouyang, K.J. et al. Mech Ageing Dev 129, 425-40.\n(3) Kaneko, H. et al. (2004) Adv Biophys 38, 45-64. (4) Epstein, C.J. et al. (1966) Medicine (Baltimore) 45, 177-221.(5) Salk, D. et al. (1985) Adv Exp Med Biol 190, 541-6.

Additional Info

Recognizes endogenous levels of total WRN. Species Crossreactivity: mouse.

Alternative Names

Werner Syndrome, RecQ Helicase-like, DKFZp686C2056, EC=3.6.4.12, EC=3.1.-.-