X-box Binding Protein 1 (XBP1) Recombinant, Human

This protein is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This gene product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response, the unfolded protein response, also increase transcription of the gene encoding this protein. This increase in transcription requires an ER stress response consensus binding element in the promoter. Adding to the list of functional possibilities is a recent report from studies of knockout mice showing that this gene is essential for hepatocyte growth. A pseudogene has been identified and localized to chromosome 5. \n\nApplications: Suitable for use in ELISA as an Antigen, Ligand, or Assay Standard. Other applications not tested.\n\nQuality Control: SDS-PAGE Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months. \n\nImportant note: This recombinant enzyme has NOT been tested with regard to biological activity.

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