Home  >  Products  >  YAP (65kD Yes-associated Protein, YAP 65, YAP65, YAP-65, Yes Associated Protein 1 65kDa, Yes-associated Protein 1, YAp 1, YAP1, YAP2)
YAP (65kD Yes-associated Protein, YAP 65, YAP65, YAP-65, Yes Associated Protein 1 65kDa, Yes-associated Protein 1, YAp 1, YAP1, YAP2)

YAP (65kD Yes-associated Protein, YAP 65, YAP65, YAP-65, Yes Associated Protein 1 65kDa, Yes-associated Protein 1, YAp 1, YAP1, YAP2)

Cat no: Y1200-01D

Supplier: United States Biological
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YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. As one of several genes of 1q22 amplicon, YAP was recently implicated in liver and breast cancer. Overexpression of YAP gene in MCF10A mammary cell line induces oncogenic transformation. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Brain and kidney lysates, and HEK 293 cell lysate Cellular Localization: Nuclear Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: Y1200-01D
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: PBS, 15% glycerol
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Sudol, M., et al. Characterization of the Mammilian YAP Gene and Its Role in Defining a Novel Protein Module, the WW Domain. JBC. 14733-14741 (1995). 2. Komuro, A., et al. WW Domain-containing Protein YAP Associates with WrbB-4 and Acts as a Co-transcriptional Activator for the Carboxyterminal Fragment of ErB4 that Translocates to the Nucleus. JBC. 33334-33341 (2003). 3. Zender, L., et al. Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach. Cell. 125:1230-3 (2006). [Western blot, Immunohistochemistry] 4. Dong, G., et al. Molecular Profiling of Transformed and Metastatic Murine Squamous Carcinoma Cells by Differential Display and cDNA Microarray Reveals Altered Expression of Multiple Genes Related to Growth, Apoptosis, Angiogenesis, and the NF-kappaB Signal Pathway. Cancer Res. 61:4797-808 (2001). 5. Overholtzer, M., et al. Transforming Properties of Yap, a Candidate Oncogene of the Chromosome 11q22 Amplicon. PNAS. 103:12405-10 (2006).
Additional info: Species Crossreactivity: This antibody reacts with the human protein.

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