Home  >  Products  >  YM201636, Phosphoinositide Kinase Inhibitor (6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3?2?:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide)

YM201636, Phosphoinositide Kinase Inhibitor (6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3?2?:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide)

Cat no: Y2065-01


Supplier: United States Biological
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Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC503nM). It inhibits p110a at higher concentration (IC50=3uM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 also blocks retroviral exit by budding from cells. Sequence: 6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3?2?:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide Solubility: DMSO, EtOH Molecular Weight: ~467.49 Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: Y2065-01
Size: 1mg
Form: Supplied as a white to off-white solid.
Purity: ~98% (NMR)

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