Cell-permeable. YM-201636 is a selective inhibitor of phosphoinositide kinase (PIK) PIKfyve (IC503nM). It inhibits p110a at higher concentration (IC50=3uM). It reversibly impairs endosomal trafficking in NIH3T3 cells, mimicking the effect produced by depleting PIKfyve with siRNA. YM-201636 also blocks retroviral exit by budding from cells.
Sequence:
6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3?2?:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide
Solubility:
DMSO, EtOH
Molecular Weight:
~467.49
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Products ![YM201636, Phosphoinositide Kinase Inhibitor (6-Amino-N-(3-(4-(4-morpholinyl)pyrido[3?2?:4,5]furo[3,2-d]pyrimidin-2-yl)phenyl)-3-pyridine carboxamide)](/system/suppliers/default_product_images/000/000/160/main/US-Biological-Life-Sciences.jpg?1386100414)
