A cell-permeable, potent, and reversible proteasome inhibitor (Ki=4nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50=3uM). Prevents g-secretase cleavage.
Peptide Sequence:
Z-Leu-Leu-Leu-CHO
Solubility:
DMSO (10mg/ml)
Molecular Weight:
~475.6
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