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Z-Leu-Leu-Leu-CHO, Z-LLL-CHO (MG-132)

Z-Leu-Leu-Leu-CHO, Z-LLL-CHO (MG-132)

Cat no: Z0720-01E

Supplier: United States Biological
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A cell-permeable, potent, and reversible proteasome inhibitor (Ki=4nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC50=3uM). Prevents g-secretase cleavage. Peptide Sequence: Z-Leu-Leu-Leu-CHO Solubility: DMSO (10mg/ml) Molecular Weight: ~475.6
Catalogue number: Z0720-01E
Size: 25mg
Form: Supplied as a solid.
Purity: ~98% (HPLC)

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