ZMIZ2, CT (PIASz1, Zinc Finger MIZ Domain-containing Protein 2, PIAS-like Protein Zimp7, HRIHFB2007, KIAA1886, ZIMP7) (Biotin)

PIASz is a members of the PIAS (protein inhibitor of activated signal transducer and activator of transcription) family of proteins, negative regulators of the Janus family of tyrosine kinase (JAK)-signal transducer and activator of transcription pathway. PIAS proteins have been shown to act as transcriptional co-regulators of multiple signaling pathways in various cellular processes. PIASz increases ligand-dependent transcriptional activity of androgen receptor and other nuclear hormone receptors, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes\n\nApplications: \nSuitable for use in ELISA and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-1:100\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

Z0725-35A-Biotin

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Muller S, et al., Nat Rev Mol Cell Biol. 2001 2(3):202-10. Review. 2. Hochstrasser M. Cell. 2001 107(1):5-8. Review. 3. Kahyo T, et al., Mol Cell. 2001 Sep;8(3):713-8. 4. Yeh ET, et al., Gene. 2000 May 2;248(1-2):1-14. Review. 5. Keane,M.M., et al., Oncogene 18 (22), 3365-3375 (1999).

Additional Info

Recognizes human ZMIZ2.