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Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic...
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the...
The neurokinin-1 (NK1) receptor is a G-protein-coupled receptor characterized by seven transmembrane helices which preferentially binds the neuropeptide...
The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel, membrane progestin receptor...
Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide,which is mainly expressed in the hypothalamus. MCH modulates feeding behavior,...
Histamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the...
Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its...
EMR2 is a member of the EGF-TM7 receptor subfamily. EGF-TM7 receptors are a family of class B, seven-span transmembrane (TM7) receptors predominantly...
Two CRF receptors, designated CRF-RI and CFR-RII, exhibit distinct brain localizations.Two forms of CFR-RII, designated CFR-RII(alpha) and CFR-RII(beta),...
The cannabinoid receptors (CB1 and CB2) are G protein-coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids.CB1...
Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein-coupled...
The cholecystokinin (CCK) family of peptide hormones have been implicated in numerous important physiologic events. These appear to be mediated through 2...
Bombesin Receptor 3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain...
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins...
G protein-coupled receptors (GPRs or GPCRs), are members of the largest protein family and play a role in many different stimulus-response pathways....
GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. G...
G2A (for G2 accumulation) is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress. G2A is predominantly...
G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra...
This is a receptor for nicotinic acid. Acts as a low affinity receptor for nicotinic acid and mediate its anti-lipolytic effect through a...
FZD3 (Frizzled 3) belongs to the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt proteins. Most frizzled...
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