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The HSP 70 family is composed of four highly conserved proteins: HSP 70, HSC 70, GRP 75 and GRP 78. These proteins serve a variety of roles: they act as...
Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn...
The bombesin receptor family includes the gastrin-releasing peptide (GRPR) and neuromedin B (NMBR) receptors. Both receptors are expressed in various brain...
Substance P (SP) and neurokinin-A (NK-A) are members of the tachykinins, and they function as modulators of the immune and hematopoietic systems. The...
The melanocortin family comprises the (alpha)-, (beta)- and (gamma)-melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these...
Histamine is an inflammatory mediator that is ubiquitously expressed and has a broad range of pharmacologic effects. Specifically, it plays a role in the...
The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically...
Glucagon, a pancreatic hormone, functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels....
The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G...
The frizzled gene, originally identified in Drosophila melanogaster, is involved in the development of tissue polarity. The mammalian homolog of frizzled, as...
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta catenin canonical signaling pathway, which leads to the activation of...
The cannabinoid receptors (CB1 and CB2) are G-protein coupled receptors that inhibit adenylate cyclase activity in response to psychoactive cannabinoids. CB1...
Cysteinyl leukotriene (CysLTs) induce intracellular calcium mobilization through the binding of two distinct seven-transmembrane, G protein-coupled...
Parathyroid hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium metabolism by...
AT1 receptor for angiotensin II. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector...
The muscarinic acetylcholine receptors (mAChR) mediate a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of...
Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response, and the inhibition of protein synthesis....
Adenosine is involved in a variety of processes, including the synthesis of urea, the anti-inflammatory response and the inhibition of protein synthesis. The...
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins...
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins...
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