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Small molecule drugs, predominantly chemically synthesized drugs with molecular weight lower than 1000 Da. These drugs are characterized by their widespread...
Humans are highly organized systems comprised of approximately 3.72x1013 cells of various types, which maintain proper organ function and normal cellular...
Glycosylation is a common type of post-translational modification (PTM) involving the covalent bonding of oligosaccharide chains to polypeptide chains. The...
Phosphorylation is the most common type of post-translational modification (PTM) that proteins undergo throughout their lifespan. The reversibility and...
Ubiquitin (Ub), a small molecule protein composed of 76 amino acids with a molecular weight of approximately 8.5 kDa, is highly conserved throughout...
Mass cytometry (CyTOF) uses specific metal isotope-labeled antibodies to mark signal molecules on and inside the cell surfaces. Cells, in the form of...
Activity-based protein profiling (ABPP) is a versatile and powerful chemoproteomic technique, utilizing activity-based probes (ABPs) that selectively and...
Drug affinity responsive target stability is a label-free small molecule probe technique under chemical proteomics first proposed by Lomenick et al. in 2009,...
Thermal proteome profiling is a combination of cellular thermal shift assay and mass spectrometry, so it is also called MS-CETSA. Thermal proteomic profiling...
To explore the local conformational function of proteins in relation to their native structural stability, Fitzgerald et al. developed a technique that...
Limited proteolysis mass spectrometry (LiP-MS) has some of the same mechanisms as DARTS. LiP-MS is a newly developed proteomics approach that combines finite...
Commercial ELISA kits play a crucial role in the preliminary phases of drug development. These kits are applicable to drugs already on the market, provided...
mRNA vaccines offer numerous benefits, including cost-effectiveness, significant R&D flexibility, high manufacturing efficiency, exceptional safety profiles,...
Native mass spectrometry (Native MS) facilitates direct determination of a protein's molecular weight. It facilitates the study of intact proteins,...
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens...
T cells play a vital role in destroying pathogens and monitoring pathological cells. They are able to distinguish between self-antigens and non-self-antigens...
To accelerate the development of cancer immunotherapy, it is essential to systematically identify tumor antigens that are truly tumor-specific,...
Receptors are biomolecules that can bind with hormones, neurotransmitters, drugs, or intracellular signaling molecules and are capable of inducing changes in...
Ion channels are made up of special proteins produced by cells, which are aggregated and embedded in the cell membrane, forming pores occupied by water...
Kinases, in simple terms, are enzymes that transfer the phosphate groups of ATP to substrates. Kinases catalyze the transfer of ?-phosphate groups of ATP to...
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