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GW1929 (N-(2-Benzoylphenyl)-L-tyrosine PPARgamma Agonist, (2S)-((2-Benzoylphenyl)amino-3-phenyl]propionic acid)
GW1929 (N-(2-Benzoylphenyl)-L-tyrosine PPARgamma Agonist, (2S)-((2-Benzoylphenyl)amino-3-phenyl]propionic acid)
United States Biological

Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis inhibitor. Apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and...

SB366791 (N-(3-Methoxyphenyl)-4-chlorocinnamide)
SB366791 (N-(3-Methoxyphenyl)-4-chlorocinnamide)
United States Biological

Potent and selective TRPV1 antagonist. Glutamatergic synaptic transmission inhibitor. Storage and Stability: Short-term Storage: +4 degrees C Long-term...

Bisindolylmaleimide III (BIM III)
Bisindolylmaleimide III (BIM III)
United States Biological

Potent and selective protein kinase C (PKC) inhibitor. Inhibits panel of protein kinases (e.g. GSK-3beta, CDK2). Storage and Stability: Short-term Storage:...

Troglitazone (5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X)
Troglitazone (5-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, BRN 4338399, CS-045, CI-991, GR 92132X)
United States Biological

Potent and selective PPARgamma agonist with no activation of PPARalpha and PPARdelta. Anti-diabetic agent with potent glucose-lowering effects and decreasing...

rac-cis-Sertraline Hydrochloride
rac-cis-Sertraline Hydrochloride
United States Biological

Potent and selective inhibitors of serotonin uptake Form: Off-White Solid Melting Point: 270-273 degrees C Solubility: DMSO, Methanol,

UK-356618
UK-356618
United States Biological

Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790,...

(R)-Roscovitine (6-Benzylamino-2-(R)-9-isopropylpurine)
(R)-Roscovitine (6-Benzylamino-2-(R)-9-isopropylpurine)
United States Biological

Potent and selective inhibitor of CDKs. More potent than olomoucine. Inhibits CDK1/cyclin B kinase (IC50 = 450 nM), CDK2 (IC50 = 700 nM) and CDK5/p35 (IC50 =...

6-ECDCA (6alpha-Ethyl-chenodeoxycholic acid, 6-alpha-ECDC, Obeticholic acid, INT-747)
6-ECDCA (6alpha-Ethyl-chenodeoxycholic acid, 6-alpha-ECDC, Obeticholic acid, INT-747)
United States Biological

Potent and selective FXR agonist (EC50= 99nM). Induces SHP in HSCs to suppress TIMP-1 expression. Apoptosis inducer. Protects against liver fibrosis...

BQ-123 sodium salt (Endothelin Receptor A Antagonist BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu) . Na)
BQ-123 sodium salt (Endothelin Receptor A Antagonist BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu) . Na)
United States Biological

Potent and selective endothelin receptor A (ETA) antagonist. Suppresses the ET-1-induced decrease of LPL activity. Shows protective effects in ischemic acute...

(R)-CR8 (2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine)
(R)-CR8 (2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine)
United States Biological

Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Potent glycogen synthase kinase (GSK-3alpha/beta)...

(S)-CR8 (2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine)
(S)-CR8 (2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurine)
United States Biological

Potent and selective cyclin-dependent kinase (CDK) 1, 2, 5, 7 and 9 inhibitor. Apoptosis inducer. Glycogen synthase kinase (GSK-3alpha/beta) inhibitor....

MTEP (3-pyridine)
MTEP (3-pyridine)
United States Biological

Potent and selective antagonist for mGluR5. 5-fold higher anxiolytic activity than MPEP. Antidepressant. Neuroprotective. Produces antiparkinsonian-like...

IWR-1-endo (4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide)
IWR-1-endo (4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide)
United States Biological

Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of b-catenin, leading to proteasomal degradation of...

ODQ (1H-Oxadiazolequinoxalin-1-one)
ODQ (1H-Oxadiazolequinoxalin-1-one)
United States Biological

Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate...

SB202190 (FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole)
SB202190 (FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole)
United States Biological

Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or...

1-Azakenpaullone (9-Bromo-7,12-dihydropyridoazepinoindol-6(5H)-one)
1-Azakenpaullone (9-Bromo-7,12-dihydropyridoazepinoindol-6(5H)-one)
United States Biological

Potent and ATP-competitive GSK-3beta (glycogen synthase kinase-3beta) inhibitor (IC50 = 18 nM). Storage and Stability: Short-term Storage: +4 degrees C...

Potassium Thioacetate
Potassium Thioacetate
United States Biological

Potassium Thioacetate is the potassium salt of Thioacetic Acid, a commonly used reagent in organic synthesis for the introduction of thiol groups in...

Nicosulfuron
Nicosulfuron
United States Biological

Post-emergence sulfonylurea herbicide. Form: White Solid Melting Point: 167-173C Solubility: Chloroform, DMSO

Nicosulfuron-d6
Nicosulfuron-d6
United States Biological

Post-emergence sulfonylurea herbicide. Form: White Solid Melting Point: 156-159C Solubility: Chloroform, Water

6-Amino-5-nitroso-3-methyluracil-d3
6-Amino-5-nitroso-3-methyluracil-d3
United States Biological

Possible inhibitor of Superoxide Dismutase. Form: Purple Solid Solubility: DMSO

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