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SAG (N-Methyl-N'-(3-pyridinylbenzyl)-N'-(3-chlorobenzothiophene-2-carbonyl)-1,4-diaminocyclohexane)
SAG (N-Methyl-N'-(3-pyridinylbenzyl)-N'-(3-chlorobenzothiophene-2-carbonyl)-1,4-diaminocyclohexane)
United States Biological

Cell permeable smoothened (Smo) agonist. Shown to induce Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an...

Bisindolylmaleimide IV (Ro 31-6233, Arcyriarubin A, BIM IV, 2,3-bis(1H-Indol-3-yl)maleimide)
Bisindolylmaleimide IV (Ro 31-6233, Arcyriarubin A, BIM IV, 2,3-bis(1H-Indol-3-yl)maleimide)
United States Biological

Cell permeable protein kinase C (PKC) inhibitor. Inhibits also protein kinase A (PKA). Storage and Stability: Short-term Storage: +4 degrees C Long-term...

SANT-2 (N-3,4,5-triethoxybenzamide)
SANT-2 (N-3,4,5-triethoxybenzamide)
United States Biological

Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. Tool to study hedgehog (Hh) signaling pathway. SAG activity inhibitor. Gli1...

Chelerythrine chloride (NSC 36405, 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride)
Chelerythrine chloride (NSC 36405, 1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride)
United States Biological

Cell permeable potent inhibitor of protein kinase C. Does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase or calcium/calmodulin-dependent...

H-89 dihydrochloride (N-5-isoquinolinesulfonamide . 2HCl)
H-89 dihydrochloride (N-5-isoquinolinesulfonamide . 2HCl)
United States Biological

Cell permeable potent and selective cAMP- and cGMP-dependent protein kinase (PKA and PKG) inhibitor. Protein kinase Cmicro (PKCmicro) inhibitor....

Latrunculin A (LAT-A, NSC 613011)
Latrunculin A (LAT-A, NSC 613011)
United States Biological

A cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1...

Latrunculin B (LAT-B, NSC 339663)
Latrunculin B (LAT-B, NSC 339663)
United States Biological

Latrunculin B is a cell-permeable marine toxin. Disrupts microfilament-mediated processes. Actin polymerization inhibitor in vitro and in vivo by the...

SAG Analog (Compound 10c, 3,4-Dichloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide)
SAG Analog (Compound 10c, 3,4-Dichloro-N-(trans-4-(methylamino)cyclohexyl)-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide)
United States Biological

Cell permeable low toxicity Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Potent activator of VEGF expression in vitro. Storage and...

Paprotrain ((Z)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile)
Paprotrain ((Z)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile)
United States Biological

Cell permeable kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and...

Bisindolylmaleimide I hydrochloride (GF 109203X, G
Bisindolylmaleimide I hydrochloride (GF 109203X, G
United States Biological

Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competitive inhibitor for the ATP-binding site of PKC....

Bisindolylmaleimide I (GF-109203X, G
Bisindolylmaleimide I (GF-109203X, G
United States Biological

Cell permeable kinase inhibitor with improved selectivity for protein kinase C (PKC) (Ki = 10 nM). Competetive inhibitor for the ATP-binding site of PKC....

SAG Analog (highly active) (Compound 10b, 3,4-Dichloro-N-(cis-4-(methylamino)cyclohexyl)-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide)
SAG Analog (highly active) (Compound 10b, 3,4-Dichloro-N-(cis-4-(methylamino)cyclohexyl)-N-(3-pyridin-4-ylbenzyl)benzo[b]thiophene-2-carboxamide)
United States Biological

Cell permeable highly active Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Storage and Stability: Short-term Storage: +4 degrees C...

GANT61 (NSC 136476, 2,2'-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine)
GANT61 (NSC 136476, 2,2'-((Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl)bis(methylene))bis(N,N-dimethyl)-benzenamine)
United States Biological

Cell permeable GLI antagonist. Inhibits Gli1 and Gli2-induced transcription. Hedgehog (Hh) signaling pathway inhibitor, downstream of SMO and SUFU. Displays...

DAPT (N-S-phenylglycine tert.butyl ester)
DAPT (N-S-phenylglycine tert.butyl ester)
United States Biological

Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks...

Swinholide A
Swinholide A
United States Biological

Cell permeable dimeric dilactone macrolide. Cytotoxic compound. Specific actin filament (F-actin) inhibitor. Disrupts the actin cytoskeleton by sequestering...

D-NMMA monoacetate (NG-Monomethyl-D-arginine . Monoacetate)
D-NMMA monoacetate (NG-Monomethyl-D-arginine . Monoacetate)
United States Biological

Cell permeable control compound for L-NMMA. Inactive, shows no NOS inhibitor activity. Useful tool to investigate non-specific L-NMMA activity. Storage and...

PD 150,606 (3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid)
PD 150,606 (3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid)
United States Biological

Cell permeable and selective calpain inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor....

AICAR (5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside)
AICAR (5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside)
United States Biological

Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor....

5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone
5-Amino-2-(3-(tert-butylamino)-2-hydroxypropoxy)acetophenone
United States Biological

Celiprolol intermediate. Form: Yellow-Brown Solid Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol

5-Nitro-2-(oxiranylmethoxy)acetophenone
5-Nitro-2-(oxiranylmethoxy)acetophenone
United States Biological

Celiprolol intermediate. Form: Off-White Solid Solubility: Chloroform, Dichloromethane, Ethyl Acetate

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