14-3-3 ? (W228) Peptide

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 beta, gamma , E, ?, ?, 0 and o. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

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SPECIFICATIONS

Catalog Number

BS1826P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide 14-3-3 ? (W228). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P63104

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1826 14-3-3 ? (W228) pAb.

Alternative Names

14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAZ; 14-3-3 protein zeta; 14-3-3 protein delta; 14-3-3 ?; 14-3-3 delta; 1433Z; KCIP1; KCIP 1