p-Arrestin-beta-1 (S412) Peptide

Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.

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SPECIFICATIONS

Catalog Number

AP0240P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide p-Arrestin-beta-1 (S412). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P49407

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using AP0240 p-Arrestin-beta-1 (S412) pAb.

Alternative Names

ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin 2; Arrestin beta 1; Arrestin beta-1; Beta-arrestin-1; Arrestin-beta1; Arrestin beta1; beta-arrestin-1